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| Kenneth Tobey | Cmdr. Pete Mathews | |
| Faith Domergue | Prof. Lesley Joyce | |
| Donald Curtis | Dr. John Carter | |
| Ian Keith | Adm. Burns | |
| Dean Maddox Jr. | Adm. Norman | |
| Chuck Griffiths | Lt. Griff / USN | |
| Harry Lauter | Deputy Bill Nash | |
| Richard W. Peterson | Capt. Stacy | |
| Tol Avery | Navy Intern | |
| William Bryant | Helicopter Pilot | |
| Del Courtney | Naval Asst. Sec. Robert David Chase | |
| Roy Engel | Control Room Officer Ordering Drop Nets | |
| Eddie Fisher | McLeod | |
| Duke Fishman | Merchant Seaman | |
| Herschel Graham | Restaurant Patron | |
| Sam Hayes | Radio Newscaster | |
| Jules Irving | King | |
| S. John Launer | Naval Doctor With Stethoscope | |
| Jack Littlefield | Aston | |
| Mike Morelli | Crew Member |
| Director |
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| Producer |
Sam Katzman
Charles H. Schneer |
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| Writer |
George Worthing Yates
Harold Jacob Smith |
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| Cinematography |
Henry Freulich
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| Musician |
Mischa Bakaleinikoff
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A giant octopus, whose feeding habits have been affected by radiation from H-Bomb tests, rises from the Mindanao Deep to terrorize the California Coast. |
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