When his former secretary (Barbara Hale) is accused of a murder, Perry Mason (Raymond Burr) gives up a judgeship to defend her

A priest is murdered and the suspect is a nun. And it's been rumored that the two of them are having an affair.

An actor rigs a fake on-air shooting with the connivance of his friend, the show's host, but the practical joke goes horribly wrong when the gun, which he'd loaded with blanks, turns out to contain a live round.

An old flame of Mason's is one of those being considered to fill a vacated government position. Now, her husband's approached by a man who says he knows his wife's secret and that if this secret should ever get out, her appointment might not push through. So, he offers to sell the information he has to him. So, when he goes to him, he finds him dead, and he is arrested for the crime and placed on trial, and Perry's asked to defend him. And Perry also suspects that the dead was hired by one of his friend's friends to steal the evidence of her secret so that they could expose it and sabotage her appointment, and in all likelihood is the killer.

Jordan White, a publisher friend of Perry, is called to a hotel where a guest, famous horror writer David Hall, has cleared out the hotel for a weekend and has called his "friends" - an actress, a fortune-teller, David's private assistant and the two remaining staff at the hotel to discuss business. They have come to the hotel as all of them are going to sue David over his new book - "The Resort" which characters are obviously based on Jordan and the guests. A practical joker, David plays tricks on them until he is thrown from the high tower of the hotel where Susan Warrenfield, the manager and owner of the hotel sees the fall and then Jordan at the tower causing the police to arrest Jordan. While Perry and Della try to solve the main mystery, Paul tries to find out who is trying to scare Susan away from the hotel. Could it really be a ghost or a more earthy visitor?...

Della meets up with an old friend, a child that she used to baby-sit and she and Perry are invited to meet the friend's new wife, Suzanne. Meanwhile, Suzanne rents out her house to four gentlemen who are having a meeting about a plan that could get them all rich - little realising that Suzanne is taping the whole conversation. Suzanne holds out for more money from her "client" before giving up the tape and is found murdered and the tape gone. As Perry, Della and Paul start to help the friend (who discovered the body and hence the prime suspect.) they discover that Suzanne used to be a Madam of a "certain kind of house", that the four "meeting" takes great pains to cover up their business and that Suzanne's past may have caught up with her...

Perry is sueing a gutter trash newspaper that is running a story about a love affair between him and Della. The editor also has "dirt" files on an Army General, his banker and other "clients". All of them make little-concealed verbal threats to him at a party but the person that hated him most is a female reporter who the editor had just fired from the paper for attempting to write a serious story. She threatens him and soon after the editor is found, floating in his pool, shot. The reporter is arrested for the crime and Perry, who has a personal stake in this matter, with the aid of Della and Paul set out to solve the mystery. But the other suspects just want the case over with and will go to any lengths to protect their pasts and their secrets...

Air Force Lt. Col. Kevin Parks was arrested and convicted for a murder of a woman and is trying to appeal for the second time when one of the first appeal lawyers, Perry, finds a new witness for the defence. The witness is threatened and then murdered to stop him giving his evidence and Perry, Della and Paul started to investigate. The main victim was very popular with the Airmen and was employed by a real estate company that was conducting a deal with the Base over a plot of land and this causes the amount of suspects and motives to rise. Paul tries to find the witness's killer and he and Capt. O'Malley are a threat to it's future...

A tennis player is accused to having killed his wife, a rich heiress. The facts are against him as he was seen in the arms of his former girlfriend in the night before the murder. This is a case for Perry Mason.

Ken Malansky is a law student attending a class being taught by Perry Mason. When a friend tells him that his girlfriend was assaulted by a fellow student, Ken rushes to the university's mock courtroom to confront him and finds him dead. The murder weapon was Ken's own knife. Perry is reluctant to take on his case, especially since the victim was the son of a close friend.

In this episode Perry Mason defends a young theatre director who is accused to have killed a famous director of a Broadway musical.

Thatcher Horton is owner of a Denver sports arena and a couple of sports teams. Bobby Spencer a friend of Ken was one of his hockey players. It seems that Horton verbally promised him that he would take care of him if he gets injured, which happened. Now it seems that Horton is reneging and he has asked Ken to represent him in his suit against Horton. Bobby threatened Horton and not long after that Horton was killed and the murder weapon was found in Bobby's possession. So Perry comes to help defend Bobby. It seems that Horton was not liked by other people including his wife and son, and it also seems that the killer was a professional assassin, so did one of them hire him?

The chief suspects in the murder of an author are the numerous colleagues whom he continuously plagiarized.

In this episode Perry Mason has to defend the son of an old friend of his who is accused to have killed an ex-officer of the Nazi-SS.

Perry Mason defends the husband of a famous rock singer who was found being killed after having had a tremendous discussion with her husband and her manager.

A young woman from Las Vegas wants that Perry Mason defends her father who is accused to having killed a man blackmailing him.

Perry is at TV station "KGGY" to be interviewed but thanks to the interference of main anchor-person Brett Huston the interview is pulled. Mostly everybody hates Brett as Brett knows all the station workers secrets. He has also written a memo insulting all of the main station players - Vic St. John - the station manager, Twyla Cooper - the producer, Chuck Gilmore - the sports reporter, Gary Slate - the weatherman, Cassie Woodfield - the reporter and Gillian Pope. Brett is shot dead with Gillian's gun and therefore is arrested for the crime. Gillian calls in Perry, Della and Ken to investigate. As Della and Perry set out to solve the mystery, Ken gets close to Cassie but she is a suspect and when it appears that somebody is trying to kill her, the mystery deepens...

A gangster who has commited all kinds of crimes is accused to have killed his wife. As he was not the murderer in this case Perry Mason intents to find the killer...

David Katz is a world famous magician and he comes to Denver with his group to perform for a charity gala for disabled children. Also there is Perry and Della as all three are supporters of the charity. Kate Ford, an assistant with an arrogant attitude, tells David that she is, from now on, going to do an illusion in which an assistant is raised in a glass coffin only to disappear when the coffin is opened up in the air (while the assistant climbs out before the coffin is raised.) After a one night stand with David, Kate is pregnant and she blackmails David with this. David and his wife Judy can't have children so that comes as a double blow to them. However Kate, with her attitude, creates much hatred at her from the rest of the group. At the gala, the glass coffin is raised but when it opens Kate's dead body falls to the ground - strangled. While Perry and Della set out to try to find the killer, Ken and PI Terry Weidner set out to find out more about Kate but they discover that nobody in Kate's home town wants to talk about her for some reason...

Dyan Draper, an editor of a well known fashion magazine, is infamous for writing columns that destroy other people's career. She also drives her employees to near madness with her orders and therefore isn't well liked. Lauren Jeffreys, the editor of another magazine, meets up with Dyan in an attempt to get Dyan not to write about her in her next column but to no avail. Lauren tries again at Dyan's place but the next time we see Dyan she is dead on the floor. Lauren is the prime suspect but she is a friend of Perry's and Della and so Perry's take the defence. Lauren had a child when she was 16 and the child grew up to be Julia Collier, Dyan's private assistant, and Lauren and Julia try to get back together. Meanwhile, Ken comes up against Albert Nardone, infamous crime mobster and little known fashion designer as Nardone's nephew gets killed by Dyan's killer and unwillingly has one of Nardone hoods 'assist' him in trying to find the killer...

Truman York a painter who died a few years ago, turns up alive when paintings supposedly painted by him show up. He goes to the gallery where they're being sold and slashes them. He then goes to his dealer to find out where these paintings are coming from. Later a guy whose wife was killed in the accident that he was supposedly killed in shows up looking for him. He goes to his wife and asks her to let him stay in her apartment, later he is killed. The guy is arrested and he calls his friend, Ken Malansky for help who in turn calls Perry.

Sleazy talk show host Ted Mayne writes a tell-all book, which enrages and embarrasses several very prominent women. One of them, actress Roxanne Shield, loses her composure during an interview and winds up making a televised death threat. Of course, when Ted is murdered, she is arrested. Witnesses claim they saw Roxanne outside his apartment that night and police later find the murder weapon in her car. Renowned defence attorney Perry Mason accepts the challenge of defending her in court.

Perry Mason is invited to the marriage of the daughter of an old friend of his. But after the ceremony the uncle of the bride is dead. Certainly this is a case for Perry Mason.

The owner of a cosmetics company is unveiling a new cream which she claims she's been using. She's been keeping her age a secret and now reveals that she's 60 and owes her appearance to the cream. She's later killed and the formula missing. Her husband is arrested and Perry defends him.

Dr Sheila Carlin is good friends with Della who calls Perry in when she is being pestered by someone. On the theory that it could be somebody that she works with at a radio stations she arranges Perry to be interviewed by Winslow Keene who is also the station's owner. Winslow enrages the rest of the talk show hosts on the station by informing them of changes that he is making to their time slots. That night, Winslow is shot by a hit man hired by someone at the station and Sheila is set up for the murder. She calls in Perry and as usual Perry, Della and Ken swing into action to find out who really did it...

On the set of a popular daytime soap opera 'Mile High', actress Kris Buckner is being forced off by co-star Mark Stratton. When she says that she'll 'kill him before she leaves the show', she makes herself the prime suspect when Stratton is murdered by someone poisoning him. As an old friend, Perry Mason comes to the help of Kris and agrees to defend her. Meanwhile Ken goes in search of information with the help of fan of the show.

Anthony Caruso, an old friend of Perry Mason, comes to Denver on the request of Dee Morrison. She's married to famed photographer David Morrison, who wants to shoot a photo featuring his former models. The tricky thing is that all of his former models are also his former wives. But Dee knows Anthony can convince them to do it which he does. And David shoots them. Later Dee catches David it what appears to be in an inappropriate situation with his assistant. They have an argument and she leaves. Later David is found dead and she's arrested and Anthony defends her. And he suspects it could have been one of the wives.

When Perry is unable to deliver a speech at a conference he calls Bill McKenzie to offer him a hotel etc in exchange for delivering the work. Also at the hotel is filming for the newest episode of 'lifestyles of the rich and famous' hosted by Adrian Lye. One of Lye's guests, and Bill's friend, Daniel Kingman (a famous chess player) is at the hotel and is being blackmailed by Lye. When he goes to Lye's room a fight ensues after which Lye is found poisoned to death. Bill defends Kingman while Ken Malansky goes after the 'waiter' seen delivering the poisoned drink to Lye's suite, assuming the drink was poisoned before delivery and not by Kingman.

Perry's secretary Della and private investigator/lawyer Ken go to visit an old friend, rancher and famous lawyer, "Wild" Bill McKenzie. Meanwhile, gubernatorial candidate Harlan Richards is murdered, and his daughter, Karen, thinks that Harlan's rival, Governor Ryan Allison, has something to do with her father death. But Ryan has had suspicions about the death and thinks that it involves somebody that is close to him. He calls Karen but when she gets there Ryan is dead and Karen framed for the crime. Bill, as a friend of the Richards family, starts to investigate, and Ken and Della are only too willing to help. This was made after Raymond Burr sadly passed away...

Bill McKenzie's niece works as a production assistant for controversial television personality Josie Joplin, who publicly accuses her of having an affair with her husband. One night McKenzie's niece receives a message which she believes is from Josie to go to her hotel room, when she gets there someone knocks her out and when she wakes up, Josie is dead and she's the number one suspect, so McKenzie defends her.