The super-strong but slow-witted and pretty much insane superhero called ""The Tick"" is assigned to defend ""The City"". Arriving there, he meets Arthur, a bank accountant who got fired for wearing his moth suit (that everyone mistakes for a bunny costume). The Tick asks Arthur to become his sidekick and reside in their headquarters: Arthur's apartment. Some criminals calling themselves ""The Idea Men"", guys who don't want to work anymore and are impossible to understand because of their full-face masks, rob a bank. They fail, thanks to the Tick, but manage to escape. They proceed to threaten to blow up the City's bank if they don't get a million bucks, so the Tick and Arthur go out once more to stop their evil ways.

The Tick, American Maid, and Arthur go undercover as caterers to infiltrate Chairface Chippendale's party. Chippendale has gathered the City's criminal underworld to witness his latest scheme - employing Professor Chromedome to inscribe Chairface's name on the Moon! The Tick blows their cover but the trio escapes Chippendale's death trap and manages to stop him before he can carve more than the first three letters of his name on the Moon.

The Tick and Arthur go on a trip to a field park about dinosaurs. There they meet Dinosaur Neil, a scientist who shows the two that he has a real dinosaur cell, but it would grow if it isn't kept in a special substance. Neil accidently eats the cell and slowly turns into a half-man, half-dinosaur monster. Arthur realizes the ""special"" substance was merely aspirin, so he gets The Tick to feed a giant aspirin to the man-beast, turning him back into a human. In the end, Neil starts talking to and dating Arthur's sister, Dot.

The Tick's mind is taken over by an evil mind controller, Mr. Mental. (Yes, the Tick actually does have a mind). Mr. Mental uses the Tick to get a machine that will increase his mind abilities even more. It's up to Arthur and his other superhero friends to break the Tick out of Mr. Mental's control

The Breadmaster and his sidekick, Buttery Pat, plot to conquer The City by baking a giant Lemon Dessert Souffle and only The Tick and Arthur can stop him. The Tick uses the Human Cannon's cannon to fire himself, create a sonic boom, and collapse the Souffle before it can crush The City.

Flowers all around the City have come alive and are attacking the citizens. The criminal responsible is the evil Spanish sunflower El Seed, who wants revenge on humans and animals for mistreating flowers. When the Tick encounters him on his cropduster, El Seed sprays the Tick with a rapid plant-growth formula, causing flowers and plants to bloom all over his body. The Tick must get the antidote to save the City and himself, while fighing El Seed and his army of corn-soldiers. Fortunately he gets some help from the Civic-Minded Five.

The Tick and the gang take Arthur's sister's car to a Superhero night club. Arthur can't get in because he's a sidekick so he has to wait in the sidekicks lounge. A pseudo-superhero calling himself the Tick comes to the club and he and The Tick battle. Also a skinny, tiny villian called the ""Evil Midnight Bomber What Bombs at Midnight"" tries to blow up the superhero night spot, with hilarious consequences.

The Tick falls prey to an uncommon cold and is a less then subtle sufferer - Arthur while tending him goes next door and is kidnapped by Thrakkorzog, evil ruler of Dimension 14B. Thrak plans to conquer Earth with an army of Tick clones, but all that an Arthur-clone can get in the way of Tick's cell samples is mucus from his handkerchiefs. This leads to the creation of Mucus Tick, whom The Tick must battle for the sake of the world!

While shopping, the Tick and Arthur run afoul of Charles, aka Brainchild - a 9-year old with his brain in a transparent dome on his head. Assisted by his cyborg dog Skippy, Charles uses his multi-mega-destructor cannon to smash the Moon into the Earth, and only the Tick can save the day!

The government asks the Tick and Arthur to help when a space capsule with a monkey (with super smarts due to exposure with cosmic rays) crash lands in Pokoponesia - the heroes must recover the monkey. The two plus American Maid go there and find themselves in battle with the country's evil ruler, Pineapple Pokopo.

The Mole Men come to the surface on vacation and the Tick ends up being their tour guide and protector - they meet supermodel Mindy Moleford and pursue her romantically. Complicating matters is the arrival of the Lava Man, who tries to kill the Mole King.

The Tick gets knocked into space and into a self-exploratory journey by a giant genetically-enhanced clown. The remaining superheroes are forced to try to fight off the evil proto-clown until the Tick returns.

The Tick blows Arthur's bank account to upgrade his apartment into their secret headquarters - when Arthur doesn't take it well, Tick moves out and forms his own HQ - a rather shaky ""Crime Tower."" Hearing that the Tick is out of action, the 115-year old Terror summons his allies, Stalingrad, the Human Ton and Handy, Tuun-La, and the Man Eating Cow, and forms a new League of Evil to kidnap the mayor. Desperate, American Maid and the Arthur send forth the Tick Signal and the Tick realizes it is his destiny to be with Arthur and fight crime - the League is no match for the assembled heroes.