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| Jack Black | Po | |
| Bryan Cranston | Li | |
| Dustin Hoffman | Shifu | |
| Angelina Jolie | Tigress | |
| J.K. Simmons | Kai | |
| Jackie Chan | Monkey | |
| Seth Rogen | Mantis | |
| Lucy Liu | Viper | |
| David Cross | Crane | |
| Kate Hudson | Mei Mei | |
| James Hong | Mr. Ping | |
| Randall Duk Kim | Oogway | |
| Steele Gagnon | Bao | |
| Liam Knight | Lei Lei | |
| Wayne Knight | Big Fun / Hom-Lee | |
| Barbara Dirickson | Grandma Panda | |
| Al Roker | Sum | |
| Willie Geist | Dim | |
| Fred Tatasciore | Master Bear | |
| Pax Jolie-Pitt | Yoo |
| Director |
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| Producer | Guillermo del Toro
Mike Mitchell Jonathan Aibel Glenn Berger |
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| Writer | Jonathan Aibel
Glenn Berger |
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| Musician |
Hans Zimmer
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Continuing his "legendary adventures of awesomeness", Po must face two hugely epic, but different threats: one supernatural and the other a little closer to his home. |
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