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| Vincent Price | Dr. Warren Chapin | |
| Judith Evelyn | Mrs. Martha Ryerson Higgins | |
| Darryl Hickman | David Morris | |
| Patricia Cutts | Isabel Stevens Chapin | |
| Pamela Lincoln | Lucy Stevens | |
| Philip Coolidge | Oliver 'Ollie' Higgins | |
| Leon Alton | Member of Silent Movie Audience | |
| Richard Barthelmess | David Kinemon | |
| Gail Bonney | Member of Silent Movie Audience | |
| William Castle | Prologue Himself - Host | |
| Pat Colby | Member of Silent Movie Audience | |
| George DeNormand | Member of Silent Movie Audience | |
| Amy Fields | Member of Silent Movie Audience | |
| Bob Gunderson | Ryerson - Screaming Convict | |
| Dal McKennon | Projectionist | |
| Clarence Straight | Member of Silent Movie Audience | |
| Ernest Torrence | Luke Hatburn / in clip from Tol'able David |
| Director |
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| Producer |
William Castle
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| Writer | Robb White
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| Cinematography |
Wilfrid M. Cline
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| Musician | Von Dexter
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After much hard work, a pathologist discovers and captures a creature that lives in every vertebrate and grows when fear grips its host. "Scream for your lives!" |
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Features
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