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| Clark Gable | Blackie Gallagher | |
| William Powell | Jim Wade | |
| Myrna Loy | Eleanor | |
| Leo Carrillo | Father Joe | |
| Nat Pendleton | Spud | |
| George Sidney | Poppa Rosen | |
| Isabel Jewell | Annabelle | |
| Muriel Evans | Tootsie Malone | |
| Thomas E. Jackson | Richard Snow | |
| Isabelle Keith | Miss Adams | |
| Frank Conroy | Defense Attorney | |
| Noel Madison | Manny Arnold | |
| Jimmy Butler | Jim - as a Boy | |
| Mickey Rooney | Blackie - as a Boy | |
| Shirley Ross | Singer in Cotton Club | |
| Oscar Apfel | Speaker of Assembly | |
| William Arnold | Blackjack Dealer | |
| William Augustin | Detective | |
| William Bailey | Al Barnes - Croupier | |
| Curtis Benton | Announcer |
| Director |
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| Producer | David O. Selznick
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| Writer |
Joseph L. Mankiewicz
Arthur Caesar Donald Ogden Stewart Oliver H.P. Garrett |
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| Cinematography |
James Wong Howe
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| Musician |
William Axt
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The friendship between two orphans endures even though they grow up on opposite sides of the law and fall in love with the same woman. |
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