The Ghost and Mrs. Fletcher is a book in the Murder, She Wrote series. In the book, Jessica Fletcher, a fictional detective and writer, cleans house to catch a killer. Jessica's friend, Eve Simpson, is trying to sell one of Cabot Cove's oldest properties, the Spencer Percy House. Eve has hired a medium to rid the house of an alleged apparition.

The Ghost and Mrs. Fletcher is the 44th book in the Murder, She Wrote series.